PO18

On October 21, 2025, a joint team led by Professor Cong Li and Associate Professor Yan You from Fudan University School of Pharmaceutical Sciences, and Professor Jianting Cai from the Second Affiliated Hospital of Zhejiang University School of Medicine, published landmark research in the internation...

Maintaining intracellular oxygen homeostasis is fundamental to normal physiological function. Hypoxia-inducible factor-1α (HIF-1α) is a master regulator of cellular responses to oxygen, participating in a wide range of biological processes. Activation of the HIF-1α pathway is commonly used to tre...

On October 4, 2025, a joint team led by Professor Cong Li from Fudan University School of Pharmaceutical Sciences, Young Investigator Xihui Gao from the School of Basic Medical Sciences, and Young Investigator Cong Wang from the School of Pharmaceutical Sciences published a landmark study in the int...

Fatty acid binding proteins (FABPs) are a family of tissue-specific expressed lipid chaperones that regulate fatty acid uptake and intracellular transport. Among the ten FABP subtypes, FABP4 and FABP5 are considered potential anti-inflammatory targets due to their significant roles in inflammation a...

Recently, a team led by Prof. Lu Zhou from School of Pharmaceutical Sciences at Fudan University, together with collaborators Prof. Liang Zhang (Shanghai Jiao Tong University), Prof. Meiqing Feng (Fudan University), and Prof. Hongkai Bi (Nanjing Medical University/Hainan Medical University), reporte...

July 31, 2025—Prof. Lu Zhou’s lab from School of Pharmaceutical Sciences, Fudan University, collaborating with Prof. Changliang Shan’s group from Nankai University, reports the development of a novel series of uncompetitive inhibitors targeting 6-phosphogluconate dehydrogenase (6PGD), a key enzyme...

Diquat, a highly toxic herbicide, can induce acute kidney injury, leading to an extremely high mortality rate. Currently, for the treatment of poisoning represented by diquat, clinical methods mainly rely on blood purification technologies. However, these technologies are unable to effectively elimi...

Considering that currently used anti-epileptic drugs (AEDs) in clinical practice can only suppress abnormal discharges without intervening in inflammatory microenvironment, combining anti-inflammatory and antioxidant agents with AEDs isprobably an effective approach to overcoming the limitations of ...

Aberrantly elevated lactate flux in tumors is increasingly recognized as a key driver of metabolic symbiosis, immunosuppression, and ultimately, immunogenic chemotherapy resistance. Here, we propose a precise lactate homeostasis modulation strategy that selectively intercepts intracellular lactate m...

Epilepsy affects over 50 million people worldwide. Despite the availability of more than 20 antiepileptic drugs, approximately 30–40% of patients continue to suffer from recurrent seizures due to drug resistance. These individuals with drug-resistant epilepsy (DRE) are at heightened risk of comorbid...

Understanding the spatiotemporal distribution of drug target proteins within cells is crucial for drug development and precision medicine. It enables rational drug design, optimizes therapeutic strategies, and minimizes off-target effects. However, due to the complex subcellular microenvironment, th...

April 13, 2025—A collaborative study led by Prof. Xiaojie Lu’s group at the Shanghai Institute of Materia Medica (Chinese Academy of Sciences), Prof. Lu Zhou’s team at Fudan University, and Prof. Yi Sun’s team from the Cancer Institute of Zhejiang University School of Medicine/Translational Medic...

Glioma is the most common malignant primary brain tumor, with surgical resection being the first-line treatment. However, due to the invasive and heterogeneous nature of glioma cells within the brain, accurately defining tumor margins remains a major clinical challenge. Incomplete resection may leav...

In the treatment of resectable solid tumors, surgery remains the basic and critical intervention. However, for highly invasive tumors, such as gliomas, which are located in the central nervous system and have indistinct boundaries, it is often difficult to completely remove the tiny residual lesions...

Epilepsy, one of the most common neurological disorders causing death and disability, is characterized by disrupted excitation–inhibition balance and aberrant synchronous neuronal discharges. Current antiepileptic therapies primarily target neuronal ion channels or neurotransmitter receptors, offeri...

Recently, Professor Jianxin Wang’s group from the School of Pharmacy, Fudan University, in collaboration with Researcher Shuangjia Zheng from Shanghai Jiao Tong University and others, published a study entitled “Geometric-aware deep learning enables discovery of bifunctional ligand-based liposomes...

Apart from the blood-brain barrier (BBB), the efficacy of immunotherapy for glioblastoma (GBM) is also limited by intrinsic immune resistance represented by extremely low immunogenicity and adaptive immune resistance represented by an immunosuppressive microenvironment. This implies the need for the...

Neovascular retinal diseases, represented by wet age-related macular degeneration (wAMD), primarily affect critical ocular tissues such as the retina and choroid. The neovascularization at these sites is highly susceptible to leakage or rupture, leading to retinal edema or hemorrhage in the macular ...

In pancreatic ductal adenocarcinoma (PDAC), stromal cells and matrix proteins form a dense physical barrier that not only confines tumor cells but also severely restricts the penetration of therapeutic agents and CD8+ T lymphocytes. Concurrently, the hyperactivated TGF-β/SMAD signaling pathway furt...

Epigenetic dysregulation in tumors has been established as a pivotal driver of malignant progression, therapeutic resistance, and the formation of a pro-tumor immune microenvironment, mediated through its influence on gene expression and metabolic reprogramming. This uncontrolled metabolic pattern, ...